5TBY

HUMAN BETA CARDIAC HEAVY MEROMYOSIN INTERACTING-HEADS MOTIF OBTAINED BY HOMOLOGY MODELING (USING SWISS-MODEL) OF HUMAN SEQUENCE FROM APHONOPELMA HOMOLOGY MODEL (PDB-3JBH), RIGIDLY FITTED TO HUMAN BETA-CARDIAC NEGATIVELY STAINED THICK FILAMENT 3D-RECONSTRUCTION (EMD-2240)

Summary for 5TBY

• Entry DOI: 10.2210/pdb5tby/pdb
• Related: 3jBH
• EMDB information: 1950 2240
• Descriptor: Myosin-7, Myosin light chain 3, Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (3 entities in total)
• Functional Keywords: contractile protein hypertrophic or dilated cardiomyopathy beta-cardiac myosin ii myosin interacting-heads motif, contractile protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 528442.65

Authors

ALAMO, L.,WARE, J.S.,PINTO, A.,GILLILAN, R.E.,SEIDMAN, J.G.,SEIDMAN, C.E.,PADRON, R. (deposition date: 2016-09-13, release date: 2017-06-07, Last modification date: 2020-01-08)

• Primary citation: Alamo, L.,Ware, J.S.,Pinto, A.,Gillilan, R.E.,Seidman, J.G.,Seidman, C.E.,Padron, R.; Effects of myosin variants on interacting-heads motif explain distinct hypertrophic and dilated cardiomyopathy phenotypes.; Elife, 6:-, 2017; PubMed: 28606303; DOI: 10.7554/eLife.24634

Experimental method

ELECTRON MICROSCOPY (20 Å)