5TBO
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM421
Summary for 5TBO
Entry DOI | 10.2210/pdb5tbo/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, 2-(1,1-difluoroethyl)-5-methyl-N-[6-(trifluoromethyl)pyridin-3-yl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, FLAVIN MONONUCLEOTIDE, ... (7 entities in total) |
Functional Keywords | oxidoreductase, alpha/beta barrel, fmn, mitochondrial membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Plasmodium falciparum (isolate 3D7) |
Total number of polymer chains | 1 |
Total formula weight | 46770.21 |
Authors | Deng, X.,Phillips, M. (deposition date: 2016-09-12, release date: 2016-09-28, Last modification date: 2023-10-04) |
Primary citation | Phillips, M.A.,White, K.L.,Kokkonda, S.,Deng, X.,White, J.,El Mazouni, F.,Marsh, K.,Tomchick, D.R.,Manjalanagara, K.,Rudra, K.R.,Wirjanata, G.,Noviyanti, R.,Price, R.N.,Marfurt, J.,Shackleford, D.M.,Chiu, F.C.,Campbell, M.,Jimenez-Diaz, M.B.,Bazaga, S.F.,Angulo-Barturen, I.,Martinez, M.S.,Lafuente-Monasterio, M.,Kaminsky, W.,Silue, K.,Zeeman, A.M.,Kocken, C.,Leroy, D.,Blasco, B.,Rossignol, E.,Rueckle, T.,Matthews, D.,Burrows, J.N.,Waterson, D.,Palmer, M.J.,Rathod, P.K.,Charman, S.A. A Triazolopyrimidine-Based Dihydroorotate Dehydrogenase Inhibitor with Improved Drug-like Properties for Treatment and Prevention of Malaria. ACS Infect Dis, 2:945-957, 2016 Cited by PubMed: 27641613DOI: 10.1021/acsinfecdis.6b00144 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.151 Å) |
Structure validation
Download full validation report