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5TBM

Crystal structure of PT2385 bound to HIF2a-B*:ARNT-B* complex

Summary for 5TBM
Entry DOI10.2210/pdb5tbm/pdb
DescriptorEndothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, ... (4 entities in total)
Functional Keywordshif2 inhibitor hif2 ligand pas-b hypoxia inducible factor 2 epas1, transcription
Biological sourceHomo sapiens (Human)
More
Cellular locationNucleus : Q99814 P27540
Total number of polymer chains2
Total formula weight27431.94
Authors
Du, X. (deposition date: 2016-09-12, release date: 2016-09-21, Last modification date: 2023-10-04)
Primary citationWallace, E.M.,Rizzi, J.P.,Han, G.,Wehn, P.M.,Cao, Z.,Du, X.,Cheng, T.,Czerwinski, R.M.,Dixon, D.D.,Goggin, B.S.,Grina, J.A.,Halfmann, M.M.,Maddie, M.A.,Olive, S.R.,Schlachter, S.T.,Tan, H.,Wang, B.,Wang, K.,Xie, S.,Xu, R.,Yang, H.,Josey, J.A.
A Small-Molecule Antagonist of HIF2 alpha Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
Cancer Res., 76:5491-5500, 2016
Cited by
PubMed: 27635045
DOI: 10.1158/0008-5472.CAN-16-0473
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

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