5TBM
Crystal structure of PT2385 bound to HIF2a-B*:ARNT-B* complex
Summary for 5TBM
Entry DOI | 10.2210/pdb5tbm/pdb |
Descriptor | Endothelial PAS domain-containing protein 1, Aryl hydrocarbon receptor nuclear translocator, 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, ... (4 entities in total) |
Functional Keywords | hif2 inhibitor hif2 ligand pas-b hypoxia inducible factor 2 epas1, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : Q99814 P27540 |
Total number of polymer chains | 2 |
Total formula weight | 27431.94 |
Authors | |
Primary citation | Wallace, E.M.,Rizzi, J.P.,Han, G.,Wehn, P.M.,Cao, Z.,Du, X.,Cheng, T.,Czerwinski, R.M.,Dixon, D.D.,Goggin, B.S.,Grina, J.A.,Halfmann, M.M.,Maddie, M.A.,Olive, S.R.,Schlachter, S.T.,Tan, H.,Wang, B.,Wang, K.,Xie, S.,Xu, R.,Yang, H.,Josey, J.A. A Small-Molecule Antagonist of HIF2 alpha Is Efficacious in Preclinical Models of Renal Cell Carcinoma. Cancer Res., 76:5491-5500, 2016 Cited by PubMed: 27635045DOI: 10.1158/0008-5472.CAN-16-0473 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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