5T8F

p110delta/p85alpha with taselisib (GDC-0032)

Summary for 5T8F

• Entry DOI: 10.2210/pdb5t8f/pdb
• Descriptor: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-1H-pyrazol-1-yl)propanamide, ... (4 entities in total)
• Functional Keywords: pi3kdelta kinase, proteros biostructures gmbh, inhibitor, lipid kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm : O00329
• Total number of polymer chains: 2
• Total formula weight: 137527.25

Authors

Moertl, M.,Steinbacher, S.,Eigenbrot, C. (deposition date: 2016-09-07, release date: 2017-01-11, Last modification date: 2023-10-04)

• Primary citation: Castanedo, G.M.,Blaquiere, N.,Beresini, M.,Bravo, B.,Brightbill, H.,Chen, J.,Cui, H.F.,Eigenbrot, C.,Everett, C.,Feng, J.,Godemann, R.,Gogol, E.,Hymowitz, S.,Johnson, A.,Kayagaki, N.,Kohli, P.B.,Knuppel, K.,Kraemer, J.,Kruger, S.,Loke, P.,McEwan, P.,Montalbetti, C.,Roberts, D.A.,Smith, M.,Steinbacher, S.,Sujatha-Bhaskar, S.,Takahashi, R.,Wang, X.,Wu, L.C.,Zhang, Y.,Staben, S.T.; Structure-Based Design of Tricyclic NF-kappa B Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).; J. Med. Chem., 60:627-640, 2017; PubMed: 28005357; DOI: 10.1021/acs.jmedchem.6b01363

Experimental method

X-RAY DIFFRACTION (2.91 Å)