5T78

Crystal structure of therapeutic mAB AR20.5 in complex with MUC1 peptide

Summary for 5T78

Entry DOI	10.2210/pdb5t78/pdb
Related	5T6P
Descriptor	Fab fragment AR20.5 - Light Chain, Fab Fragment - AR20.5 - Heavy chain, MUC1 Glycopeptide, ... (5 entities in total)
Functional Keywords	antibody, fab, immune system
Biological source	Mus musculus More
Total number of polymer chains	6
Total formula weight	96243.62
Authors	Brooks, C.L.,Movahedin, M. (deposition date: 2016-09-02, release date: 2017-01-11, Last modification date: 2023-10-04)
Primary citation	Movahedin, M.,Brooks, T.M.,Supekar, N.T.,Gokanapudi, N.,Boons, G.J.,Brooks, C.L. Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen. Glycobiology, 27:677-687, 2017 Cited by PubMed: 28025250 DOI: 10.1093/glycob/cww131 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation