5T4V

Crystal structure of the bromodomain of human BRPF1 in complex with NI-48 ligand

Summary for 5T4V

• Entry DOI: 10.2210/pdb5t4v/pdb
• Descriptor: Peregrin, 4-cyano-N-(7-methoxy-1,4-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzene-1-sulfonamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: transcription, structural genomics, structural genomics consortium, sgc
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P55201
• Total number of polymer chains: 1
• Total formula weight: 14195.21

Authors

Tallant, C.,Igoe, N.,Bayle, E.D.,Nunez-Alonso, G.,Newman, J.A.,Mathea, S.,Savitsky, P.,Fedorov, O.,Brennan, P.E.,Muller, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Fish, P.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-08-30, release date: 2017-02-08, Last modification date: 2024-01-17)

• Primary citation: Igoe, N.,Bayle, E.D.,Fedorov, O.,Tallant, C.,Savitsky, P.,Rogers, C.,Owen, D.R.,Deb, G.,Somervaille, T.C.,Andrews, D.M.,Jones, N.,Cheasty, A.,Ryder, H.,Brennan, P.E.,Muller, S.,Knapp, S.,Fish, P.V.; Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.; J. Med. Chem., 60:668-680, 2017; PubMed: 28068087; DOI: 10.1021/acs.jmedchem.6b01583

Experimental method

X-RAY DIFFRACTION (1.65 Å)