5T3Q
Crystal structure of the c-Met kinase domain in complex with a pyrazolone inhibitor
5T3Q の概要
エントリーDOI | 10.2210/pdb5t3q/pdb |
関連するPDBエントリー | 3U6I |
分子名称 | Hepatocyte growth factor receptor, N-{3-fluoro-4-[(7-methoxyquinolin-4-yl)oxy]phenyl}-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide (3 entities in total) |
機能のキーワード | phosphotransferase, cancer, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Membrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 35772.30 |
構造登録者 | |
主引用文献 | Boezio, A.A.,Peterson, E.A.,Harmange, J.-C. Discovery of AMG337: Using structure guided scaffold hydridization to optimize physicochemical properties and target coverage of a MET kinase inhibitor to be published, |
実験手法 | X-RAY DIFFRACTION (2 Å) |
構造検証レポート
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