5T2M

mPI3Kd IN COMPLEX WITH 7m

Summary for 5T2M

Entry DOI	10.2210/pdb5t2m/pdb
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 4-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]benzamide (3 entities in total)
Functional Keywords	mi3kd, inhibitor, transferase
Biological source	Mus musculus (Mouse)
Cellular location	Cytoplasm : O35904
Total number of polymer chains	1
Total formula weight	108178.07
Authors	Petersen, J.,Terstige, I.,Perry, M.,Svensson, T.,Tyrchan, C.,Lindmark, H.,Oster, L. (deposition date: 2016-08-23, release date: 2017-04-19)
Primary citation	Terstiege, I.,Perry, M.,Petersen, J.,Tyrchan, C.,Svensson, T.,Lindmark, H.,Oster, L. Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors. Bioorg. Med. Chem. Lett., 27:679-687, 2017 Cited by PubMed: 28017532 DOI: 10.1016/j.bmcl.2016.11.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation