5T0L
Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-15)
5T0L の概要
エントリーDOI | 10.2210/pdb5t0l/pdb |
分子名称 | Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
機能のキーワード | toxoplasma gondii, dhfr, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Toxoplasma gondii |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 132169.21 |
構造登録者 | |
主引用文献 | Welsch, M.E.,Zhou, J.,Gao, Y.,Yan, Y.,Porter, G.,Agnihotri, G.,Li, Y.,Lu, H.,Chen, Z.,Thomas, S.B. Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design. ACS Med Chem Lett, 7:1124-1129, 2016 Cited by PubMed: 27994750DOI: 10.1021/acsmedchemlett.6b00328 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.13 Å) |
構造検証レポート
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