Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5T0L

Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF and 5-(4-(3,4-dichlorophenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-15)

5T0L の概要
エントリーDOI10.2210/pdb5t0l/pdb
分子名称Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
機能のキーワードtoxoplasma gondii, dhfr, inhibitor, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
由来する生物種Toxoplasma gondii
タンパク質・核酸の鎖数2
化学式量合計132169.21
構造登録者
Thomas, S.B.,Chen, Z.,Lu, H.,Li, Y. (登録日: 2016-08-16, 公開日: 2016-09-28, 最終更新日: 2023-10-04)
主引用文献Welsch, M.E.,Zhou, J.,Gao, Y.,Yan, Y.,Porter, G.,Agnihotri, G.,Li, Y.,Lu, H.,Chen, Z.,Thomas, S.B.
Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design.
ACS Med Chem Lett, 7:1124-1129, 2016
Cited by
PubMed: 27994750
DOI: 10.1021/acsmedchemlett.6b00328
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (3.13 Å)
構造検証レポート
Validation report summary of 5t0l
検証レポート(詳細版)ダウンロードをダウンロード

217157

件を2024-03-13に公開中

PDB statisticsPDBj update infoContact PDBjnumon