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5SXD

Crystal Structure of PI3Kalpha in complex with fragment 22

Summary for 5SXD
Entry DOI10.2210/pdb5sxd/pdb
Related5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX8 5SX9 5SXA 5SXB 5SXC 5SXE 5SXF 5SXI 5SXJ 5SXK
DescriptorPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 2-methoxybenzoic acid (3 entities in total)
Functional Keywordslipid kinase, phosphoinositide, 3-kinase, signaling, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight161801.64
Authors
Gabelli, S.B.,Vogelstein, B.,Miller, M.S.,Amzel, L.M. (deposition date: 2016-08-09, release date: 2017-02-15, Last modification date: 2023-10-04)
Primary citationMiller, M.S.,Maheshwari, S.,McRobb, F.M.,Kinzler, K.W.,Amzel, L.M.,Vogelstein, B.,Gabelli, S.B.
Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design.
Bioorg. Med. Chem., 25:1481-1486, 2017
Cited by
PubMed: 28129991
DOI: 10.1016/j.bmc.2017.01.012
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.5 Å)
Structure validation

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