5SX8

Crystal Structure of PI3Kalpha in complex with fragments 12 and 15

Summary for 5SX8

Entry DOI	10.2210/pdb5sx8/pdb
Related	5SW8 5SWG 5SWO 5SWP 5SWR 5SWT 5SX9 5SXA 5SXB 5SXC 5SXD 5SXE 5SXF 5SXI 5SXJ 5SXK
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 6-methylpyridin-2-amine, ... (4 entities in total)
Functional Keywords	lipid kinase, phosphoinositide, 3-kinase, signaling, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	161949.91
Authors	Gabelli, S.B.,Vogelstein, B.,Miller, M.S.,Amzel, L.M. (deposition date: 2016-08-09, release date: 2017-02-15, Last modification date: 2023-10-04)
Primary citation	Miller, M.S.,Maheshwari, S.,McRobb, F.M.,Kinzler, K.W.,Amzel, L.M.,Vogelstein, B.,Gabelli, S.B. Identification of allosteric binding sites for PI3K alpha oncogenic mutant specific inhibitor design. Bioorg. Med. Chem., 25:1481-1486, 2017 Cited by PubMed: 28129991 DOI: 10.1016/j.bmc.2017.01.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.47 Å)

Structure validation