5SVS

Anomalous Mn2+ signal reveals a divalent cation-binding site in the head domain of the ATP-gated human P2X3 ion channel

Summary for 5SVS

• Entry DOI: 10.2210/pdb5svs/pdb
• Related: 5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVR 5SVT
• Descriptor: P2X purinoceptor 3, 2-acetamido-2-deoxy-beta-D-glucopyranose, MAGNESIUM ION, ... (7 entities in total)
• Functional Keywords: membrane protein, ion channel, anomalous signal mg ion
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 41713.13

Authors

Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E. (deposition date: 2016-08-07, release date: 2016-09-28, Last modification date: 2020-07-29)

• Primary citation: Mansoor, S.E.,Lu, W.,Oosterheert, W.,Shekhar, M.,Tajkhorshid, E.,Gouaux, E.; X-ray structures define human P2X3 receptor gating cycle and antagonist action.; Nature, 538:66-71, 2016; PubMed: 27626375; DOI: 10.1038/nature19367

Experimental method

X-RAY DIFFRACTION (4.025 Å)