5OWW

Crystal structure of human BRD4(1) bromodomain in complex with UT22B

Summary for 5OWW

Entry DOI	10.2210/pdb5oww/pdb
Descriptor	Bromodomain-containing protein 4, ~{N}-(3-methylbenzotriazol-5-yl)-1-(phenylmethyl)imidazole-2-carboxamide (3 entities in total)
Functional Keywords	brd4 bromodomain 1(brp4(1)), inhibitor, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	61726.96
Authors	Zhu, J.,Caflisch, A. (deposition date: 2017-09-04, release date: 2018-10-10, Last modification date: 2024-01-17)
Primary citation	Batiste, L.,Unzue, A.,Dolbois, A.,Hassler, F.,Wang, X.,Deerain, N.,Zhu, J.,Spiliotopoulos, D.,Nevado, C.,Caflisch, A. Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple). Acs Cent.Sci., 4:180-188, 2018 Cited by PubMed: 29532017 DOI: 10.1021/acscentsci.7b00401 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation