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5OOR

Structure of CHK1 10-pt. mutant complex with staurosporine

Summary for 5OOR
Entry DOI10.2210/pdb5oor/pdb
Related5OOP
DescriptorSerine/threonine-protein kinase Chk1, STAUROSPORINE, CHLORIDE ION, ... (4 entities in total)
Functional Keywordsparkinson's disease, leucine-rich repeat kinase 2, lrrk2, checkpoint kinase 1, chk1, mutant, surrogate, kinase inhibitor, transferase, staurosporine
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: O14757
Total number of polymer chains1
Total formula weight34596.19
Authors
Dokurno, P.,Williamson, D.S.,Acheson-Dossang, P.,Chen, I.,Murray, J.B.,Shaw, T.,Surgenor, A.E. (deposition date: 2017-08-08, release date: 2017-10-25, Last modification date: 2024-01-17)
Primary citationWilliamson, D.S.,Smith, G.P.,Acheson-Dossang, P.,Bedford, S.T.,Chell, V.,Chen, I.J.,Daechsel, J.C.A.,Daniels, Z.,David, L.,Dokurno, P.,Hentzer, M.,Herzig, M.C.,Hubbard, R.E.,Moore, J.D.,Murray, J.B.,Newland, S.,Ray, S.C.,Shaw, T.,Surgenor, A.E.,Terry, L.,Thirstrup, K.,Wang, Y.,Christensen, K.V.
Design of Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitors Using a Crystallographic Surrogate Derived from Checkpoint Kinase 1 (CHK1).
J. Med. Chem., 60:8945-8962, 2017
Cited by
PubMed: 29023112
DOI: 10.1021/acs.jmedchem.7b01186
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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