5O2S

Human KRAS in complex with darpin K27

Summary for 5O2S

• Entry DOI: 10.2210/pdb5o2s/pdb
• Descriptor: GTPase KRas, darpin K27, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: kras, ras signalling, darpin, nucleotide exchange, signaling protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
• Total number of polymer chains: 8
• Total formula weight: 156828.29

Authors

Debreczeni, J.E.,Guillard, S.,Kolasinska-Zwierz, P.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Stocki, P.,Mistry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R. (deposition date: 2017-05-22, release date: 2017-07-26)

• Primary citation: Guillard, S.,Kolasinska-Zwierz, P.,Debreczeni, J.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Overman, R.,Stocki, P.,Mistry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R.; Structural and functional characterization of a DARPin which inhibits Ras nucleotide exchange.; Nat Commun, 8:16111-16111, 2017; PubMed: 28706291; DOI: 10.1038/ncomms16111

Experimental method

X-RAY DIFFRACTION (3.22 Å)