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5O1A

p53 cancer mutant Y220C in complex with compound MB240

Summary for 5O1A
Entry DOI10.2210/pdb5o1a/pdb
DescriptorCellular tumor antigen p53, ZINC ION, [3,5-bis(iodanyl)-2-oxidanyl-4-pyrrol-1-yl-phenyl]-(4-methylpiperazin-1-yl)methanone, ... (5 entities in total)
Functional Keywordsp53, tumor suppressor, cancer mutation, protein stabilization, small-molecule stabilizers, cancer therapy, dna binding protein, molecular chaperones
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
Total number of polymer chains2
Total formula weight50358.80
Authors
Joerger, A.C.,Bauer, M.R.,Baud, M.G.J.,Fersht, A.R. (deposition date: 2017-05-18, release date: 2018-05-09, Last modification date: 2024-01-17)
Primary citationBaud, M.G.J.,Bauer, M.R.,Verduci, L.,Dingler, F.A.,Patel, K.J.,Horil Roy, D.,Joerger, A.C.,Fersht, A.R.
Aminobenzothiazole derivatives stabilize the thermolabile p53 cancer mutant Y220C and show anticancer activity in p53-Y220C cell lines.
Eur J Med Chem, 152:101-114, 2018
Cited by
PubMed: 29702446
DOI: 10.1016/j.ejmech.2018.04.035
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.44 Å)
Structure validation

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