5NU1

Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds

Summary for 5NU1

Entry DOI	10.2210/pdb5nu1/pdb
Descriptor	Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, ~{N}-[4-(3-chlorophenyl)-5-(2-chlorophenyl)carbonyl-1,3-thiazol-2-yl]-2-(4-ethylsulfonylphenyl)ethanamide, ... (4 entities in total)
Functional Keywords	nuclear hormone receptor, ligand-binding domain, inverse agonist, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	65236.83
Authors	Kallen, J. (deposition date: 2017-04-28, release date: 2017-06-21, Last modification date: 2024-01-17)
Primary citation	Kallen, J.,Izaac, A.,Be, C.,Arista, L.,Orain, D.,Kaupmann, K.,Guntermann, C.,Hoegenauer, K.,Hintermann, S. Structural States of ROR gamma t: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds. ChemMedChem, 12:1014-1021, 2017 Cited by PubMed: 28590087 DOI: 10.1002/cmdc.201700278 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation