5NQH

Structure of the human Fe65-PTB2 homodimer

Summary for 5NQH

Entry DOI	10.2210/pdb5nqh/pdb
Descriptor	Amyloid beta A4 precursor protein-binding family B member 1, SULFATE ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	alzheimers disease, phosphotyrosine-binding (ptb) domain, signaling protein, homodimerization
Biological source	Homo sapiens (Human)
Cellular location	Cell membrane: O00213
Total number of polymer chains	4
Total formula weight	62875.61
Authors	Feilen, L.P.,Haubrich, K.,Sinning, I.,Konietzko, U.,Kins, S.,Simon, B.,Wild, K. (deposition date: 2017-04-20, release date: 2017-05-03, Last modification date: 2024-01-17)
Primary citation	Feilen, L.P.,Haubrich, K.,Strecker, P.,Probst, S.,Eggert, S.,Stier, G.,Sinning, I.,Konietzko, U.,Kins, S.,Simon, B.,Wild, K. Fe65-PTB2 Dimerization Mimics Fe65-APP Interaction. Front Mol Neurosci, 10:140-140, 2017 Cited by PubMed: 28553201 DOI: 10.3389/fnmol.2017.00140 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation