5NLK

Crystal structure of CREBBP bromodomain complexd with US13A

Summary for 5NLK

Entry DOI	10.2210/pdb5nlk/pdb
Descriptor	CREB-binding protein, ~{N}-[3-acetamido-5-[(5-ethanoyl-2-ethoxy-phenyl)carbamoyl]phenyl]furan-2-carboxamide (3 entities in total)
Functional Keywords	inhibitor, bromodomain, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm: Q92793
Total number of polymer chains	1
Total formula weight	14672.81
Authors	Zhu, J.,Caflisch, A. (deposition date: 2017-04-04, release date: 2018-02-21, Last modification date: 2024-01-17)
Primary citation	Batiste, L.,Unzue, A.,Dolbois, A.,Hassler, F.,Wang, X.,Deerain, N.,Zhu, J.,Spiliotopoulos, D.,Nevado, C.,Caflisch, A. Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple). ACS Cent Sci, 4:180-188, 2018 Cited by PubMed: 29532017 DOI: 10.1021/acscentsci.7b00401 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation