5NJK

PTB domain of human Numb isoform-1

Summary for 5NJK

Entry DOI	10.2210/pdb5njk/pdb
Descriptor	Protein numb homolog, ALA-TYR-ILE-GLY-PRO-PTR-LEU, SULFATE ION, ... (4 entities in total)
Functional Keywords	ptb domain, numb, breast cancer, endocytosis
Biological source	Homo sapiens (Human) More
Cellular location	Membrane; Peripheral membrane protein: P49757
Total number of polymer chains	12
Total formula weight	113013.58
Authors	Mapelli, M.,Di Fiore, P.P. (deposition date: 2017-03-29, release date: 2017-12-13, Last modification date: 2024-01-17)
Primary citation	Colaluca, I.N.,Basile, A.,Freiburger, L.,D'Uva, V.,Disalvatore, D.,Vecchi, M.,Confalonieri, S.,Tosoni, D.,Cecatiello, V.,Malabarba, M.G.,Yang, C.J.,Kainosho, M.,Sattler, M.,Mapelli, M.,Pece, S.,Di Fiore, P.P. A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer. J. Cell Biol., 217:745-762, 2018 Cited by PubMed: 29269425 DOI: 10.1083/jcb.201709092 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.13 Å)

Structure validation