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5NCY

mPI3Kd IN COMPLEX WITH inh1

Summary for 5NCY
Entry DOI10.2210/pdb5ncy/pdb
DescriptorPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, 1,2-ETHANEDIOL, SULFATE ION, ... (5 entities in total)
Functional Keywordsmi3kd, inhibitor, complex pi3k, transferase
Biological sourceMus musculus (Mouse)
Cellular locationCytoplasm : O35904
Total number of polymer chains1
Total formula weight108364.29
Authors
Petersen, J. (deposition date: 2017-03-06, release date: 2017-06-21, Last modification date: 2017-07-05)
Primary citationPerry, M.W.D.,Bjorhall, K.,Bonn, B.,Carlsson, J.,Chen, Y.,Eriksson, A.,Fredlund, L.,Hao, H.,Holden, N.S.,Karabelas, K.,Lindmark, H.,Liu, F.,Pemberton, N.,Petersen, J.,Rodrigo Blomqvist, S.,Smith, R.W.,Svensson, T.,Terstiege, I.,Tyrchan, C.,Yang, W.,Zhao, S.,Oster, L.
Design and Synthesis of Soluble and Cell-Permeable PI3K delta Inhibitors for Long-Acting Inhaled Administration.
J. Med. Chem., 60:5057-5071, 2017
Cited by
PubMed: 28520415
DOI: 10.1021/acs.jmedchem.7b00401
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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