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5N1Y

HLA-A02 carrying MVWGPDPLYV

Replaces:  5C0H
Summary for 5N1Y
Entry DOI10.2210/pdb5n1y/pdb
Related5C07 5C08 5C09 5C0A 5C0B 5C0D 5C0F 5C0G 5C0I 5C0J 5COD 5COE 5HYJ
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, MVWGPDPLYV, ... (6 entities in total)
Functional Keywordsimmuno, hla-a02, 1e6-tcr, cross-rteactivity, immune system
Biological sourceHomo sapiens (Human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted . Note=(Microbial infection) In the presence of M: P61769
Total number of polymer chains3
Total formula weight46127.31
Authors
Rizkallah, P.J.,Bulek, A.M.,Cole, D.K.,Sewell, A.K. (deposition date: 2017-02-06, release date: 2017-02-15, Last modification date: 2024-01-17)
Primary citationCole, D.K.,Bulek, A.M.,Dolton, G.,Schauenberg, A.J.,Szomolay, B.,Rittase, W.,Trimby, A.,Jothikumar, P.,Fuller, A.,Skowera, A.,Rossjohn, J.,Zhu, C.,Miles, J.J.,Peakman, M.,Wooldridge, L.,Rizkallah, P.J.,Sewell, A.K.
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
J. Clin. Invest., 126:2191-2204, 2016
Cited by
PubMed: 27183389
DOI: 10.1172/JCI85679
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.39 Å)
Structure validation

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