5MY4

Structure of Pyroglutamate-Abeta-specific Fab c#17 in complex with human Abeta-pE3-12PEGb

Summary for 5MY4

Entry DOI	10.2210/pdb5my4/pdb
Descriptor	Fab c#17 light chain, Fab c#17 heavy chain, Pyroglutamate-Abeta pE3-12-PEGb, ... (4 entities in total)
Functional Keywords	alzheimer's disease, pyroglutamate abeta, monoclonal antibody, fibrillation, immune system
Biological source	Mus musculus More
Total number of polymer chains	3
Total formula weight	49951.45
Authors	Parthier, C.,Piechotta, A.,Stubbs, M.T. (deposition date: 2017-01-25, release date: 2017-06-28, Last modification date: 2024-01-17)
Primary citation	Piechotta, A.,Parthier, C.,Kleinschmidt, M.,Gnoth, K.,Pillot, T.,Lues, I.,Demuth, H.U.,Schilling, S.,Rahfeld, J.U.,Stubbs, M.T. Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292:12713-12724, 2017 Cited by PubMed: 28623233 DOI: 10.1074/jbc.M117.777839 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.211 Å)

Structure validation