5MRH

Crystal structure of the Vps10p domain of human sortilin/NTS3 in complex with Triazolone 1

Summary for 5MRH

Entry DOI	10.2210/pdb5mrh/pdb
Descriptor	Sortilin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(3-methylbutyl)-4~{H}-1,2,3-triazol-5-one, ... (5 entities in total)
Functional Keywords	receptor, vsp10p, sortilin, signaling protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	78945.06
Authors	Andersen, J.L.,Strandbygaard, D.,Thirup, S. (deposition date: 2016-12-23, release date: 2017-05-17, Last modification date: 2024-01-17)
Primary citation	Andersen, J.L.,Lindberg, S.,Langgard, M.,Maltas, P.J.,Ronn, L.C.B.,Bundgaard, C.,Strandbygaard, D.,Thirup, S.,Watson, S.P. The identification of novel acid isostere based inhibitors of the VPS10P family sorting receptor Sortilin. Bioorg. Med. Chem. Lett., 27:2629-2633, 2017 Cited by PubMed: 28462834 DOI: 10.1016/j.bmcl.2017.02.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation