5MQK
Crystal structure of CREBBP bromodomain complexed with CBP019
Summary for 5MQK
| Entry DOI | 10.2210/pdb5mqk/pdb |
| Descriptor | CREB-binding protein, 1-(1-methylindol-3-yl)ethanone (3 entities in total) |
| Functional Keywords | crebbp bromodomain, inhibitor, transcription |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 28793.12 |
| Authors | Zhu, J.,Spiliotopoulos, D.,Caflisch, A. (deposition date: 2016-12-20, release date: 2017-04-19, Last modification date: 2019-10-16) |
| Primary citation | Spiliotopoulos, D.,Zhu, J.,Wamhoff, E.C.,Deerain, N.,Marchand, J.R.,Aretz, J.,Rademacher, C.,Caflisch, A. Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain. Bioorg. Med. Chem. Lett., 27:2472-2478, 2017 Cited by PubMed: 28410781DOI: 10.1016/j.bmcl.2017.04.001 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.53 Å) |
Structure validation
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