5MMW
Crystal structure of the Retinoid X Receptor alpha in complex with synthetic honokiol derivative 6 and a fragment of the TIF2 co-activator.
Summary for 5MMW
Entry DOI | 10.2210/pdb5mmw/pdb |
Descriptor | Retinoic acid receptor RXR-alpha, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, (~{E})-3-[3-(2-methyl-3-phenyl-phenyl)-4-oxidanyl-phenyl]prop-2-enoic acid, ... (4 entities in total) |
Functional Keywords | rxr tif2 honokiol transcription, transcription |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus : P19793 |
Total number of polymer chains | 2 |
Total formula weight | 27024.47 |
Authors | Andrei, S.A.,Brunsveld, L.,Scheepstra, M.,Ottmann, C. (deposition date: 2016-12-12, release date: 2017-11-08, Last modification date: 2024-01-17) |
Primary citation | Scheepstra, M.,Andrei, S.A.,de Vries, R.M.J.M.,Meijer, F.A.,Ma, J.N.,Burstein, E.S.,Olsson, R.,Ottmann, C.,Milroy, L.G.,Brunsveld, L. Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization. ACS Chem Neurosci, 8:2065-2077, 2017 Cited by PubMed: 28691794DOI: 10.1021/acschemneuro.7b00216 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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