5MLA

Crystal structure of human RAS in complex with darpin K55

Summary for 5MLA

• Entry DOI: 10.2210/pdb5mla/pdb
• Descriptor: GTPase KRas, darpin k55, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: ras, darpin, nucleotide exchange, inhibition, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116
• Total number of polymer chains: 2
• Total formula weight: 40407.30

Authors

Debreczeni, J.E.,Guillard, S.,Kolasinska-Zwierz, P.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Overman, R.,Stocki, P.,Mistry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R. (deposition date: 2016-12-06, release date: 2017-12-20)

• Primary citation: Guillard, S.,Kolasinska-Zwierz, P.,Debreczeni, J.,Breed, J.,Zhang, J.,Bery, N.,Marwood, R.,Tart, J.,Overman, R.,Stocki, P.,Minstry, B.,Phillips, C.,Rabbitts, T.,Jackson, R.,Minter, R.; Inhibition of RAS nucleotide exchange by a DARPin: structural characterisation and effects on downstream signalling by active RAS; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.19 Å)