5MFP

Human Sirt6 in complex with activator UBCS58

Summary for 5MFP

• Entry DOI: 10.2210/pdb5mfp/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (9 entities in total)
• Functional Keywords: 4-(pyridin-3-yl)pyrrolo[1, 2-a]quinoxaline, drug, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus, nucleoplasm : Q8N6T7
• Total number of polymer chains: 2
• Total formula weight: 70460.43

Authors

Steegborn, C.,You, W.,Kambach, C. (deposition date: 2016-11-18, release date: 2016-12-28, Last modification date: 2024-01-17)

• Primary citation: You, W.,Rotili, D.,Li, T.M.,Kambach, C.,Meleshin, M.,Schutkowski, M.,Chua, K.F.,Mai, A.,Steegborn, C.; Structural Basis of Sirtuin 6 Activation by Synthetic Small Molecules.; Angew. Chem. Int. Ed. Engl., 56:1007-1011, 2017; PubMed: 27990725; DOI: 10.1002/anie.201610082

Experimental method

X-RAY DIFFRACTION (1.98 Å)