5M81

Translation initiation factor 4E in complex with (SP)-iPr-m7GppSpG mRNA 5' cap analog

Summary for 5M81

• Entry DOI: 10.2210/pdb5m81/pdb
• Descriptor: Eukaryotic translation initiation factor 4E, [[[(3~{a}~{R},4~{R},6~{R},6~{a}~{R})-4-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-7-ium-9-yl)-2,2-dimethyl-3~{a},4,6,6~{a}-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methoxy-oxidanyl-phosphoryl]oxy-sulfanyl-phosphoryl] [(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate, GLYCEROL, ... (4 entities in total)
• Functional Keywords: protein-ligand complex, translation initiation factor, eif4e, ipr-m7gppspg, phosphorothioate, mrna 5' cap analog, translation
• Biological source: Mus musculus (Mouse)
• Cellular location: Cytoplasm, P-body : P63073
• Total number of polymer chains: 4
• Total formula weight: 92295.01

Authors

Warminski, M.,Nowak, E.,Kowalska, J.,Jemielity, J.,Nowotny, M. (deposition date: 2016-10-28, release date: 2017-12-20, Last modification date: 2024-01-17)

• Primary citation: Warminski, M.,Nowak, E.,Kubacka, D.,Kowalska, J.,Nowotny, M.,Jemielity, J.; Translation initiation factor 4E in complex with (SP)-iPr-m7GppSpG mRNA 5' cap analog; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.9 Å)