5LYQ

Crystal structure of the Retinoic Acid Receptor alpha in complex with a synthetic spiroketal agonist and a fragment of the TIF2 co-activator.

Summary for 5LYQ

• Entry DOI: 10.2210/pdb5lyq/pdb
• Descriptor: Retinoic acid receptor RXR-alpha, HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP, (2~{R})-6,6,9,9-tetramethylspiro[3,4,7,8-tetrahydrobenzo[g]chromene-2,2'-3,4-dihydrochromene]-6'-carboxylic acid, ... (4 entities in total)
• Functional Keywords: nuclear receptor, rxr, spiroketal, transcription
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : P19793
• Total number of polymer chains: 2
• Total formula weight: 28842.42

Authors

Andrei, S.A.,Ottmann, C. (deposition date: 2016-09-28, release date: 2017-04-26, Last modification date: 2024-01-17)

• Primary citation: Scheepstra, M.,Andrei, S.A.,Unver, M.Y.,Hirsch, A.K.H.,Leysen, S.,Ottmann, C.,Brunsveld, L.,Milroy, L.G.; Designed Spiroketal Protein Modulation.; Angew. Chem. Int. Ed. Engl., 56:5480-5484, 2017; PubMed: 28407400; DOI: 10.1002/anie.201612504

Experimental method

X-RAY DIFFRACTION (2.17 Å)