5LYH

Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H10

Summary for 5LYH

• Entry DOI: 10.2210/pdb5lyh/pdb
• Related: 5LXP
• Descriptor: Poly [ADP-ribose] polymerase 14, 3-[2-[4-[2-[[4-[(3-aminocarbonylphenyl)amino]-4-oxidanylidene-butanoyl]amino]ethyl]-1,2,3-triazol-1-yl]ethylsulfamoyl]benzoic acid (3 entities in total)
• Functional Keywords: adp-ribosylation, inhibitor complex, transferase domain, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : Q460N5
• Total number of polymer chains: 2
• Total formula weight: 45352.34

Authors

Karlberg, T.,Thorsell, A.G.,Schuler, H. (deposition date: 2016-09-28, release date: 2016-12-21, Last modification date: 2024-01-17)

• Primary citation: Peng, B.,Thorsell, A.G.,Karlberg, T.,Schuler, H.,Yao, S.Q.; Small Molecule Microarray Based Discovery of PARP14 Inhibitors.; Angew. Chem. Int. Ed. Engl., 56:248-253, 2017; PubMed: 27918638; DOI: 10.1002/anie.201609655

Experimental method

X-RAY DIFFRACTION (2.17 Å)