5LY1

JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND Macrocyclic PEPTIDE Inhibitor CP2 (13-mer)

Summary for 5LY1

• Entry DOI: 10.2210/pdb5ly1/pdb
• Related: 2OX0 2YBP 4AI9 4BIS 4V2V 5LY2
• Descriptor: Lysine-specific demethylase 4A, CP2, NICKEL (II) ION, ... (8 entities in total)
• Functional Keywords: jmjd2a, kdm4a, oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, oxygenase, double-stranded beta helix, dsbh, facial triad, demethylase, histone, jmjc domain, metal binding protein, epigenetic and transcription regulation, chromatin regulator, hydroxylation
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus : O75164
• Total number of polymer chains: 5
• Total formula weight: 180504.67

Authors

King, O.N.F.,Chowdhury, R.,Kawamura, A.,Schofield, C.J. (deposition date: 2016-09-23, release date: 2017-04-12, Last modification date: 2024-01-17)

• Primary citation: Kawamura, A.,Munzel, M.,Kojima, T.,Yapp, C.,Bhushan, B.,Goto, Y.,Tumber, A.,Katoh, T.,King, O.N.,Passioura, T.,Walport, L.J.,Hatch, S.B.,Madden, S.,Muller, S.,Brennan, P.E.,Chowdhury, R.,Hopkinson, R.J.,Suga, H.,Schofield, C.J.; Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.; Nat Commun, 8:14773-14773, 2017; PubMed: 28382930; DOI: 10.1038/ncomms14773

Experimental method

X-RAY DIFFRACTION (2.5 Å)