5LXP
Human PARP14 (ARTD8), catalytic fragment in complex with inhibitor H5
Summary for 5LXP
Entry DOI | 10.2210/pdb5lxp/pdb |
Descriptor | Poly [ADP-ribose] polymerase 14, ~{N}'-(3-aminocarbonylphenyl)-~{N}-[[1-[(2~{R})-2-phenylpropyl]-1,2,3-triazol-4-yl]methyl]pentanediamide (3 entities in total) |
Functional Keywords | adp-ribosylation, inhibitor complex, transferase domain, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q460N5 |
Total number of polymer chains | 2 |
Total formula weight | 45134.22 |
Authors | Karlberg, T.,Thorsell, A.G.,Schuler, H. (deposition date: 2016-09-22, release date: 2016-12-21, Last modification date: 2024-01-17) |
Primary citation | Peng, B.,Thorsell, A.G.,Karlberg, T.,Schuler, H.,Yao, S.Q. Small Molecule Microarray Based Discovery of PARP14 Inhibitors. Angew. Chem. Int. Ed. Engl., 56:248-253, 2017 Cited by PubMed: 27918638DOI: 10.1002/anie.201609655 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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