5LVQ

Crystal structure of human PCAF bromodomain in complex with compound-D (CPD-D), N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide

Summary for 5LVQ

Entry DOI	10.2210/pdb5lvq/pdb
Descriptor	Histone acetyltransferase KAT2B, 1,2-ETHANEDIOL, N-methyl-2-(tetrahydro-2H-pyran-4-yloxy)benzamide, ... (5 entities in total)
Functional Keywords	signaling protein, bromodomain, histone acetyltransferase kat2b, histone, acetylation, acetyllysine, epigenetics, structural genomics consortium (sgc), transferase
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : Q92831
Total number of polymer chains	2
Total formula weight	28968.49
Authors	Chaikuad, A.,Filippakopoulos, P.,von Delft, F.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Hopkins, A.L.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2016-09-14, release date: 2016-10-26, Last modification date: 2017-01-11)
Primary citation	Navratilova, I.,Aristotelous, T.,Picaud, S.,Chaikuad, A.,Knapp, S.,Filappakopoulos, P.,Hopkins, A.L. Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening. ACS Med Chem Lett, 7:1213-1218, 2016 Cited by PubMed: 27994766 DOI: 10.1021/acsmedchemlett.6b00154 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation