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5LVP

Human PDK1 Kinase Domain in Complex with an HM-Peptide Bound to the PIF-Pocket

Summary for 5LVP
Entry DOI10.2210/pdb5lvp/pdb
Descriptor3-phosphoinositide-dependent protein kinase 1, hydrophobic-motif peptide of PKB/Akt, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
Functional Keywordsprotein kinase, allosteric regulation, small compounds, pif-pocket, transferase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains8
Total formula weight149715.93
Authors
Schulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Suess, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M. (deposition date: 2016-09-14, release date: 2016-10-19, Last modification date: 2019-10-16)
Primary citationSchulze, J.O.,Saladino, G.,Busschots, K.,Neimanis, S.,Su, E.,Odadzic, D.,Zeuzem, S.,Hindie, V.,Herbrand, A.K.,Lisa, M.N.,Alzari, P.M.,Gervasio, F.L.,Biondi, R.M.
Bidirectional Allosteric Communication between the ATP-Binding Site and the Regulatory PIF Pocket in PDK1 Protein Kinase.
Cell Chem Biol, 23:1193-1205, 2016
Cited by
PubMed: 27693059
DOI: 10.1016/j.chembiol.2016.06.017
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.5 Å)
Structure validation

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