6EO7

X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue

Replaces:  5LUY

Summary for 6EO7

• Entry DOI: 10.2210/pdb6eo7/pdb
• Related PRD ID: PRD_000020
• Descriptor: GA68B2 - MODIFIED HUMAN THROMBIN BINDING APTAMER, Prothrombin, POTASSIUM ION, ... (8 entities in total)
• Functional Keywords: alpha thrombin, aptamer, thrombin-mtba, complex, hydrolase-dna complex, hydrolase, hydrolase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 39440.18

Authors

Dolot, R.M.,Nawrot, B.,Yang, X. (deposition date: 2017-10-09, release date: 2017-10-18, Last modification date: 2024-01-17)

• Primary citation: Dolot, R.,Lam, C.H.,Sierant, M.,Zhao, Q.,Liu, F.W.,Nawrot, B.,Egli, M.,Yang, X.; Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.; Nucleic Acids Res., 46:4819-4830, 2018; PubMed: 29684204; DOI: 10.1093/nar/gky268

Experimental method

X-RAY DIFFRACTION (2.24 Å)