5LUX
Homeobox transcription factor CDX1 bound to methylated DNA
Summary for 5LUX
Entry DOI | 10.2210/pdb5lux/pdb |
Descriptor | DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*CP*CP*TP*C)-3'), Homeobox protein CDX-1, DNA (5'-D(P*TP*TP*GP*TP*GP*TP*TP*TP*TP*AP*(5CM)P*GP*AP*CP*CP*TP*CP*C)-3'), ... (6 entities in total) |
Functional Keywords | transcription, transcription factor, methylated dna |
Biological source | Homo sapiens (Human) More |
Cellular location | Nucleus: P47902 |
Total number of polymer chains | 6 |
Total formula weight | 37274.32 |
Authors | Morgunova, E.,Popov, A.,Taipale, J. (deposition date: 2016-09-12, release date: 2017-05-17, Last modification date: 2024-01-17) |
Primary citation | Yin, Y.,Morgunova, E.,Jolma, A.,Kaasinen, E.,Sahu, B.,Khund-Sayeed, S.,Das, P.K.,Kivioja, T.,Dave, K.,Zhong, F.,Nitta, K.R.,Taipale, M.,Popov, A.,Ginno, P.A.,Domcke, S.,Yan, J.,Schubeler, D.,Vinson, C.,Taipale, J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science, 356:-, 2017 Cited by PubMed: 28473536DOI: 10.1126/science.aaj2239 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.23 Å) |
Structure validation
Download full validation report