Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6EO6

X-ray structure of the complex between human alpha-thrombin and modified 15-mer DNA aptamer containing 5-(3-(2-(1H-indol-3-yl)acetamide-N-yl)-1-propen-1-yl)-2'-deoxyuridine residue

Replaces:  5LUW
Summary for 6EO6
Entry DOI10.2210/pdb6eo6/pdb
Related PRD IDPRD_000020
DescriptorGA63A - TBA MODIFIED APTAMER, Prothrombin, POTASSIUM ION, ... (8 entities in total)
Functional Keywordsalpha thrombin, aptamer, thrombin-mtba, complex, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight39555.31
Authors
Dolot, R.M.,Nawrot, B.,Yang, X. (deposition date: 2017-10-09, release date: 2017-10-25, Last modification date: 2024-01-17)
Primary citationDolot, R.,Lam, C.H.,Sierant, M.,Zhao, Q.,Liu, F.W.,Nawrot, B.,Egli, M.,Yang, X.
Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.
Nucleic Acids Res., 46:4819-4830, 2018
Cited by
PubMed: 29684204
DOI: 10.1093/nar/gky268
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.69 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon