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5LUQ

Crystal Structure of Human DNA-dependent Protein Kinase Catalytic Subunit (DNA-PKcs)

Summary for 5LUQ
Entry DOI10.2210/pdb5luq/pdb
DescriptorDNA-dependent protein kinase catalytic subunit,DNA-dependent Protein Kinase Catalytic Subunit,DNA-dependent protein kinase catalytic subunit, C-terminal fragment of KU80 (KU80ct194) (2 entities in total)
Functional Keywordsdna-pkcs, kinase, dna repair, nhej, double strand break repair, heat repeat, transferase
Biological sourceHomo sapiens
More
Cellular locationNucleus : P78527
Total number of polymer chains4
Total formula weight972480.57
Authors
Sibanda, B.L.,Chirgadze, D.Y.,Ascher, D.B.,Blundell, T.L. (deposition date: 2016-09-09, release date: 2017-02-15, Last modification date: 2018-03-28)
Primary citationSibanda, B.L.,Chirgadze, D.Y.,Ascher, D.B.,Blundell, T.L.
DNA-PKcs structure suggests an allosteric mechanism modulating DNA double-strand break repair.
Science, 355:520-524, 2017
Cited by
PubMed: 28154079
DOI: 10.1126/science.aak9654
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (4.3 Å)
Structure validation

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