5LSO

Crystal structure of SPF45 UHM domain with cyclic peptide inhibitor

Summary for 5LSO

Entry DOI	10.2210/pdb5lso/pdb
Descriptor	Splicing factor 45, LYS-SER-ARG-TRP-ASP-GLU (3 entities in total)
Functional Keywords	uhm domain, splicing-inhibitor complex, splicing/inhibitor
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	24712.35
Authors	Jagtap, P.K.A.,Garg, D.,Sattler, M. (deposition date: 2016-09-05, release date: 2016-10-26, Last modification date: 2024-01-17)
Primary citation	Jagtap, P.K.,Garg, D.,Kapp, T.G.,Will, C.L.,Demmer, O.,Luhrmann, R.,Kessler, H.,Sattler, M. Rational Design of Cyclic Peptide Inhibitors of U2AF Homology Motif (UHM) Domains To Modulate Pre-mRNA Splicing. J. Med. Chem., 59:10190-10197, 2016 Cited by PubMed: 27753493 DOI: 10.1021/acs.jmedchem.6b01118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation