5LRX

Structure of A20 OTU domain bound to ubiquitin

Summary for 5LRX

Entry DOI	10.2210/pdb5lrx/pdb
Descriptor	Tumor necrosis factor alpha-induced protein 3, Polyubiquitin-B (3 entities in total)
Functional Keywords	hydrolase, protease, deubiquitinase, otu domain
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm. A20p50: Cytoplasm: P21580 P21580 Ubiquitin: Cytoplasm : P0CG47
Total number of polymer chains	6
Total formula weight	191241.44
Authors	Mevissen, T.E.T.,Kulathu, Y.,Mulder, M.P.C.,Geurink, P.P.,Maslen, S.L.,Gersch, M.,Elliott, P.R.,Burke, J.E.,van Tol, B.D.M.,Akutsu, M.,El Oualid, F.,Kawasaki, M.,Freund, S.M.V.,Ovaa, H.,Komander, D. (deposition date: 2016-08-22, release date: 2016-10-19, Last modification date: 2017-09-13)
Primary citation	Mevissen, T.E.,Kulathu, Y.,Mulder, M.P.,Geurink, P.P.,Maslen, S.L.,Gersch, M.,Elliott, P.R.,Burke, J.E.,van Tol, B.D.,Akutsu, M.,El Oualid, F.,Kawasaki, M.,Freund, S.M.,Ovaa, H.,Komander, D. Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne. Nature, 538:402-405, 2016 Cited by PubMed: 27732584 DOI: 10.1038/nature19836 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation