5LQF

CDK1/CyclinB1/CKS2 in complex with NU6102

Summary for 5LQF

• Entry DOI: 10.2210/pdb5lqf/pdb
• Descriptor: Cyclin-dependent kinase 1, G2/mitotic-specific cyclin-B1, Cyclin-dependent kinases regulatory subunit 2, ... (5 entities in total)
• Functional Keywords: cdk1 cyclin b cks2 cell cycle nu6102, transferase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: P06493; Cytoplasm: P14635
• Total number of polymer chains: 6
• Total formula weight: 153233.71

Authors

Coxon, C.R.,Anscombe, E.,Harnor, S.J.,Martin, M.P.,Carbain, B.J.,Hardcastle, I.R.,Harlow, L.K.,Korolchuk, S.,Matheson, C.J.,Noble, M.E.,Newell, D.R.,Turner, D.M.,Sivaprakasam, M.,Wang, L.Z.,Wong, C.,Golding, B.T.,Griffin, R.J.,Endicott, J.A.,Cano, C. (deposition date: 2016-08-17, release date: 2017-01-11, Last modification date: 2024-01-10)

• Primary citation: Coxon, C.R.,Anscombe, E.,Harnor, S.J.,Martin, M.P.,Carbain, B.,Golding, B.T.,Hardcastle, I.R.,Harlow, L.K.,Korolchuk, S.,Matheson, C.J.,Newell, D.R.,Noble, M.E.,Sivaprakasam, M.,Tudhope, S.J.,Turner, D.M.,Wang, L.Z.,Wedge, S.R.,Wong, C.,Griffin, R.J.,Endicott, J.A.,Cano, C.; Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines.; J. Med. Chem., 60:1746-1767, 2017; PubMed: 28005359; DOI: 10.1021/acs.jmedchem.6b01254

Experimental method

X-RAY DIFFRACTION (2.06 Å)