5LPT

tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group P21) with 6-amino-2-(methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5,6-tetramethoxytetrahydro-2H-pyran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one

Summary for 5LPT

• Entry DOI: 10.2210/pdb5lpt/pdb
• Related: 1P0D 4KWO 4LEQ 4PUK 5I00 5I02 5I06 5I07 5LPO 5LPP 5LPQ 5LPS
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, 6-azanyl-2-(methylamino)-4-[2-[(2~{R},3~{R},4~{S},5~{R},6~{S})-3,4,5,6-tetramethoxyoxan-2-yl]ethyl]-1,7-dihydroimidazo[4,5-g]quinazolin-8-one, ... (5 entities in total)
• Functional Keywords: carbohydrate-based inhibitors, homodimer, shigellosis, transferase, transferase inhibitor
• Biological source: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
• Total number of polymer chains: 2
• Total formula weight: 87183.51

Authors

Ehrmann, F.R.,Heine, A.,Klebe, G. (deposition date: 2016-08-14, release date: 2017-08-30, Last modification date: 2024-01-10)

• Primary citation: Ehrmann, F.R.,Botzanowski, T.,Pfaffender, T.,Heine, A.,Diederich, F.,Sanglier-Cianferani, S.,Klebe, G.; Carbohydrate-based Inhibitors targeting the Ribose-34 pocket of Z.mobilis TGT and changing the oligomeric state of the homodimer; To be published,

Experimental method

X-RAY DIFFRACTION (2.36 Å)