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5LPS

tRNA guanine Transglycosylase (TGT) in co-crystallized complex (space group C2) with 6-amino-2-(methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5,6-tetramethoxytetrahydro-2H-pyran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one

Summary for 5LPS
Entry DOI10.2210/pdb5lps/pdb
Related1P0D 4KWO 4LEQ 4PUK 5I00 5I02 5I06 5I07 5LPO 5LPP 5LPQ
DescriptorQueuine tRNA-ribosyltransferase, 6-azanyl-2-(methylamino)-4-[2-[(2~{R},3~{R},4~{S},5~{R},6~{S})-3,4,5,6-tetramethoxyoxan-2-yl]ethyl]-1,7-dihydroimidazo[4,5-g]quinazolin-8-one, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywordscarbohydrate-based inhibitors, homodimer, shigellosis, transferase, transferase inhibitor
Biological sourceZymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Total number of polymer chains1
Total formula weight43515.68
Authors
Ehrmann, F.R.,Heine, A.,Klebe, G. (deposition date: 2016-08-14, release date: 2017-08-30, Last modification date: 2024-01-10)
Primary citationEhrmann, F.R.,Botzanowski, T.,Pfaffender, T.,Heine, A.,Diederich, F.,Sanglier-Cianferani, S.,Klebe, G.
Carbohydrate-based Inhibitors targeting the Ribose-34 pocket of Z.mobilis TGT and changing the oligomeric state of the homodimer
To be published,
Experimental method
X-RAY DIFFRACTION (1.27 Å)
Structure validation

217705

PDB entries from 2024-03-27

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