5LM6
VIM-2 metallo-beta-lactamase in complex with 2-(3-fluoro-4-hydroxyphenyl)-3-oxoisoindoline-4-carboxylic acid (compound 35)
Summary for 5LM6
| Entry DOI | 10.2210/pdb5lm6/pdb |
| Descriptor | Metallo-beta-lactamase VIM-2, ZINC ION, FORMIC ACID, ... (5 entities in total) |
| Functional Keywords | metallo-beta-lactamase, inhibitor, complex, antibiotic resistance, hydrolase |
| Biological source | Pseudomonas aeruginosa |
| Total number of polymer chains | 2 |
| Total formula weight | 57569.47 |
| Authors | Li, G.-B.,Brem, J.,Someya, H.,McDonough, M.A.,Schofield, C.J. (deposition date: 2016-07-29, release date: 2017-02-15, Last modification date: 2024-01-10) |
| Primary citation | Li, G.B.,Abboud, M.I.,Brem, J.,Someya, H.,Lohans, C.T.,Yang, S.Y.,Spencer, J.,Wareham, D.W.,McDonough, M.A.,Schofield, C.J. NMR-filtered virtual screening leads to non-metal chelating metallo-beta-lactamase inhibitors. Chem Sci, 8:928-937, 2017 Cited by PubMed: 28451231DOI: 10.1039/c6sc04524c PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.17 Å) |
Structure validation
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