5LM4
Structure of the thermostalilized EAAT1 cryst-II mutant in complex with L-ASP and the allosteric inhibitor UCPH101
Summary for 5LM4
| Entry DOI | 10.2210/pdb5lm4/pdb |
| Related | 5LLM |
| Descriptor | Excitatory amino acid transporter 1,Neutral amino acid transporter B(0),Excitatory amino acid transporter 1, SODIUM ION, ASPARTIC ACID, ... (4 entities in total) |
| Functional Keywords | excitatory amino acid transporter 1, human glutamate transporter, slc1a3, ucph101, transport protein |
| Biological source | Homo sapiens (Human) More |
| Cellular location | Membrane; Multi-pass membrane protein: P43003 |
| Total number of polymer chains | 1 |
| Total formula weight | 57038.89 |
| Authors | Canul-Tec, J.,Assal, R.,Legrand, P.,Reyes, N. (deposition date: 2016-07-29, release date: 2017-04-19, Last modification date: 2024-01-10) |
| Primary citation | Canul-Tec, J.C.,Assal, R.,Cirri, E.,Legrand, P.,Brier, S.,Chamot-Rooke, J.,Reyes, N. Structure and allosteric inhibition of excitatory amino acid transporter 1. Nature, 544:446-451, 2017 Cited by PubMed: 28424515DOI: 10.1038/nature22064 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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