5LJ1

N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one

Summary for 5LJ1

Entry DOI	10.2210/pdb5lj1/pdb
Descriptor	Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 8-(((3R,4R,5S)-3-((4,4-difluorocyclohexyl)methoxy)-5-methoxypiperidin-4-yl)amino)-3-methyl-5-(5-methylpyridin-3-yl)-1,7-naphthyridin-2(1H)-one, ... (4 entities in total)
Functional Keywords	inhibitor, histone, epigenetic reader, bromodomain, brd4, bromodomain containing protein 4, antagonist, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: O60885
Total number of polymer chains	1
Total formula weight	15689.05
Authors	Chung, C.,Bamborough, P.,Demont, E. (deposition date: 2016-07-17, release date: 2016-08-31, Last modification date: 2016-09-14)
Primary citation	Bamborough, P.,Chung, C.W.,Demont, E.H.,Furze, R.C.,Bannister, A.J.,Che, K.H.,Diallo, H.,Douault, C.,Grandi, P.,Kouzarides, T.,Michon, A.M.,Mitchell, D.J.,Prinjha, R.K.,Rau, C.,Robson, S.,Sheppard, R.J.,Upton, R.,Watson, R.J. A Chemical Probe for the ATAD2 Bromodomain. Angew.Chem.Int.Ed.Engl., 55:11382-11386, 2016 Cited by PubMed: 27530368 DOI: 10.1002/anie.201603928 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation