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5LF3

Human 20S proteasome complex with Bortezomib at 2.1 Angstrom

Summary for 5LF3
Entry DOI10.2210/pdb5lf3/pdb
DescriptorProteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-5, ... (20 entities in total)
Functional Keywordsproteasome, multicatalytic proteinase, ntn-hydrolase, hydrolase
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains28
Total formula weight725716.20
Authors
Schrader, J.,Henneberg, F.,Mata, R.,Tittmann, K.,Schneider, T.R.,Stark, H.,Bourenkov, G.,Chari, A. (deposition date: 2016-06-30, release date: 2016-08-17, Last modification date: 2024-01-10)
Primary citationSchrader, J.,Henneberg, F.,Mata, R.A.,Tittmann, K.,Schneider, T.R.,Stark, H.,Bourenkov, G.,Chari, A.
The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
Science, 353:594-598, 2016
Cited by
PubMed: 27493187
DOI: 10.1126/science.aaf8993
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

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