5LCK

A Clickable Covalent ERK 1/2 Inhibitor

Summary for 5LCK

Entry DOI	10.2210/pdb5lck/pdb
Descriptor	Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-[2-[[2-[(5-methoxypyridin-3-yl)amino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]propanamide, ... (4 entities in total)
Functional Keywords	erk2 covalent inhibitor, transferase
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm, cytoskeleton, spindle : P28482
Total number of polymer chains	1
Total formula weight	42413.54
Authors	O'Reilly, M.,Wright, D. (deposition date: 2016-06-22, release date: 2016-07-20, Last modification date: 2018-03-28)
Primary citation	Lebraud, H.,Wright, D.J.,East, C.E.,Holding, F.P.,O'Reilly, M.,Heightman, T.D. In-gel activity-based protein profiling of a clickable covalent ERK1/2 inhibitor. Mol Biosyst, 12:2867-2874, 2016 Cited by PubMed: 27385078 DOI: 10.1039/c6mb00367b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation