5LAZ

Novel Spiro[3H-indole-3,2 -pyrrolidin]-2(1H)-one Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND BI-0252

Summary for 5LAZ

Entry DOI	10.2210/pdb5laz/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, 4-[(2~{R},3~{a}~{S},5~{S},6~{S},6~{a}~{S})-6'-chloranyl-6-(3-chloranyl-2-fluoranyl-phenyl)-4-(cyclopropylmethyl)-2'-oxidanylidene-spiro[1,2,3,3~{a},6,6~{a}-hexahydropyrrolo[3,2-b]pyrrole-5,3'-1~{H}-indole]-2-yl]benzoic acid, ZINC ION, ... (5 entities in total)
Functional Keywords	vienna, ppi, mdm2, hdm2, bi, ligase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	11739.85
Authors	Kessler, D.,Gollner, A. (deposition date: 2016-06-15, release date: 2016-11-02, Last modification date: 2019-06-12)
Primary citation	Gollner, A.,Rudolph, D.,Arnhof, H.,Bauer, M.,Blake, S.M.,Boehmelt, G.,Cockroft, X.L.,Dahmann, G.,Ettmayer, P.,Gerstberger, T.,Karolyi-Oezguer, J.,Kessler, D.,Kofink, C.,Ramharter, J.,Rinnenthal, J.,Savchenko, A.,Schnitzer, R.,Weinstabl, H.,Weyer-Czernilofsky, U.,Wunberg, T.,McConnell, D.B. Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction. J. Med. Chem., 59:10147-10162, 2016 Cited by PubMed: 27775892 DOI: 10.1021/acs.jmedchem.6b00900 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation